New research suggests that patients who stop using new weight-loss injections like Mounjaro or Wegovy can put back on shed pounds far faster than those who stop conventional diet and exercise plans.
Research printed in a major health publication points out that while overweight people often shed substantial amounts of their total mass while on the medication, the mass comes back at an average rate of 0.8 kg per month upon discontinuation.
"Users purchasing these drugs should be aware of the danger of rapid weight regain when the medication concludes," warns researcher Dr. Susan Jebb.
This pace of recovery suggests a reversion to starting weight in about a year and a half.
Comparing Treatments
The research, which reviewed dozens of trials involving over 9,000 of patients, compared the outcomes of GLP-1 agonists with other pills.
Scientists emphasize that people who shed pounds through dieting usually experience a more gradual creep back—perhaps 100 grams monthly—after stopping.
Explaining the Rapid Rebound
Doctors propose the mechanism of the drugs is key to understanding the amplified rebound.
These medications imitate a natural hormone called GLP-1, which controls feelings of fullness.
"Sustained high doses of GLP-1 concentrations far above than the body's typical production might result in the system to generate a reduced amount of its own natural hormone, and could diminish sensitivity to its effects," explained Dr. Adam Collins, a nutrition expert.
"Stopping of this hormone supplement results in appetite is no longer kept in check, making binge eating far more likely."
A Chronic Condition?
The NHS suggest the injections for individuals with weight-linked medical conditions, accompanied by recommended diet and exercise modifications.
Professionals say that, considering the significant potential of weight regain, the treatment should be considered long-term.
This perspective is echoed by drug manufacturers, who say that the results "underscore the persistent nature of excess weight," comparing it to managing conditions like hypertension.
Patient Accounts
Users who have stopped the medication describe a sudden resurgence of cravings.
"It was like something flipping and you become starving," said an individual.
This difficulty is exacerbated if individuals have not established sustainable lifestyle or habit changes during treatment.
Widespread Use
Recent estimates indicate that a significant number of people in the UK have used these injections in the last 12 months, with interest continuing to grow.
- Adoption is more common among women than males.
- The middle-aged age group shows the greatest usage rates.
- A large proportion access the medications through private prescriptions rather than public health services.
Ultimately, experts emphasize that while the jabs are potent agents for weight loss, they are not a permanent cure and maintained weight loss hinges on integrated behavioural changes.
